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Alfa-lipoic Acid ntụ ntụ (1077-28-7)

Alfa-lipoic acid / thioctic acid ntụ ntụ bụ kemịkalụ nwere vitamin dịka a na-akpọ antioxidant. Yist, imeju, akụrụ, inine, broccoli, na poteto bụ ezigbo isi mmalite nkealpha-lipoic acid / thioctic acid. A na-emekwa ya n'ime ụlọ nyocha maka ojiji dị ka ọgwụ. A na-ejikarị Alpha-lipoic acid / thioctic acid ewere ọnụ maka ọrịa shuga na ihe mgbaàmà metụtara akwara nke ọrịa shuga gụnyere ọkụ, mgbu, na ụfụ na ụkwụ na ogwe aka. A na-enyekwa ya dị ka ogwu n'ime akwara (site na IV) maka otu ojiji ndị a. A na-anabata ọgwụ dị elu nke alpha-lipoic acid / thioctic acid na Germany maka ọgwụgwọ nke mgbaàmà ndị a metụtara ọrịa a.

Rụpụta: Ogbe Production
ngwugwu: 1KG / akpa, 25KG / ịgbà
Wisepowder nwere ikike imepụta na ịnye nnukwu ọnụọgụ. Mmepụta niile n'okpuru ọnọdụ cGMP na usoro njikwa mma siri ike, akwụkwọ nnwale niile na nlele dị.

Ozi Alfa-lipoic Acid powder base base

 

aha Alfa-lipoic Acid ntụ ntụ
CAS 1077-28-7
ọcha 98%
Aha aha (+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) - Alfa-lipoic Acid / Thioctic acid; (RS) -α-Lipoic Acid
Synonyms DL-Alpha-lipoic Acid / Mmiri Thioctic; Liposan; Lọtọtị; NSC 628502; NSC 90788; Protogen A; Thioctsan; Nkechi;
molekụla Formula C8H14O2S2
molekụla arọ 206.318 g / mol
Melting Point 60-62 Celsius
KeyInChI AGBQKNBQESQNJD-UHFFFAOYSA-N
ụdị Solid
ọdịdị Ìhè na-acha odo odo na-acha odo odo
Ọkara ndụ Nkeji 30 ruo 1 awa
Solubility Nsogbu na Chloroform (Jiri nwayọ), DMSO (Nke dị ntakịrị), Methanol (Nke obere)
nchekwa Ọnọdụ Akọrọ, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).
ngwa Onye na - eme metabolism ume.
Akwụkwọ Nnwale dị
Alfa-lipoic Acid
Foto ntụ ntụ
Light Yellow

 

Kedu ihe bụ alfa lipoic acid?

Alfa-lipoic acid bụ antioxidant sitere na caprylic acid. Aha ya ndị ọzọ bụ ALA, lipoic acid, Biletan, Lipoicin, Thioctan, wdg aha kemịkal ya bụ 1,2-dithiolane-3-pentanoic acid ma ọ bụ acid thioctic. Ọ bụ ogige organosulfur a na -emepụta ya n'ahụ mmadụ na anụmanụ. Mmepụta ya sitere na octanoic acid na cysteine ​​dị ka sọlfọ. Ọ bụ ihe dị mkpa maka metabolism nke ikuku n'ime ahụ. Ọ dị na sel ọ bụla ma na -enyere aka imepụta ume site na glucose.

Ọ nwere ọtụtụ ọrụ cellular na molekul, n'ihi ikike antioxidant ya. Omume antioxidant a nke alfa-lipoic acid welitere mmasị ya maka iji ya dị ka ihe na-edozi ahụ. A na -ejikwa ya dị ka onye na -ahụ maka ọgwụgwọ. Ọ nwere ike bụrụ ọgwụgwọ ga -ekwe omume na ọrịa shuga, oke ibu, neuropathy kpatara n'ihi ọrịa shuga, ọgwụgwọ ọnya, melite ọnọdụ akpụkpọ ahụ, wdg.

Alfa-lipoic acid ntụ ntụ nwere ọkara ndụ nke nkeji 30 ruo otu awa. Ọ na -agbaze ntakịrị na chloroform, dimethyl sulfoxide (DMSO), na methanol. Enwere ike nweta ya site na akwụkwọ nri, yist, broccoli, poteto, anụ dị ka imeju na akụrụ.

Oke kachasị nke onye okenye nwere ike ị takeụ n’ụbọchị bụ 2400mg.

 

Kedu ka Alpha-lipoic Acid si arụ ọrụ?

Alfa-lipoic acid nwere ihe antioxidant. Ọ pụtara na ọ nwere ike na -agbasi mbọ ike megide radicals n'efu na ahụ wee belata ihe merenụ dị ka ịka nká ma na -enyere aka idobe mkpụrụ ndụ ahụike.

A na -emepụta ya na mitochondria ma na -arụ ọrụ dị ka ihe nrụpụta dị mkpa maka ịkụda enzymes na nri. Ọ na -aghọgbukwa ion metal ma belata ụdị oxidized nke antioxidants ndị ọzọ dị ka vitamin C, Vitamin E, na glutathione. Ọ nwekwara ike megharịa ha.Alpha-lipoic acid dị mkpa maka ịchịkwa ụdị ikuku oxygen na-arụ ọrụ.

Alfa-lipoic acid na-akwalite sistemụ nchebe antioxidant. Ọ na-eme nke a site na ngosipụta mkpụrụ ndụ ihe nketa nke Nrf-2. Ọ na -agbanwekwa mkpụrụ ndụ ihe nketa chọrọ peroxisome proliferator iji mee ka ha rụọ ọrụ.

Alfa-lipoic acid na-egbochikwa ihe na-akpata nuklia kappa B. Ọ na-eme ka protein kinase AMPK (AMPK) rụọ ọrụ na akwara ọkpụkpụ ma na-ebute omume metabolic dị iche iche.

Enwere ụdị alpha-lipoic acid abụọ. Ha bụ lipoic acid oxidized (LA) na belatara dihydrolipoic acid (DHLA). A na -emepụta DHLA na mitochondria nwere sel n'ime ahụ. Nke a ga -ekwe omume na nicotinamide adenine dinucleotide hydrogen (NADH) na lipoamide dehydrogenase. Ihe abuo abuo a na enyere aka na mmeghari mgbanwe a.

N'ime sel ndị na-enweghị mitochondria, alfa-lipoic acid nwere ike belata na DHLA site na nicotinamide adenine dinucleotide phosphate (NADPH). A na -enyere ihe a aka site na glutathione na thioredoxin reductases.

Alfa-lipoic acid nwere ihe pụrụ iche nke na-eme ka ọ dị iche na glutathione. Ọ bụ ezie na naanị ụdị glutathione belatara bụ ọgwụ antioxidant, ụdị alfa-lipoic acid belatara na nke na-anaghị ebelata bụ antioxidants siri ike.

Alfa-lipoic acid na-etinyekwa na idozi protein ndị oxidized ma nwee ike nyere aka n'ịhazi usoro ntụgharị mkpụrụ ndụ ihe nketa.

Alfa-lipoic acid nwekwara ihe mgbochi mkpali. Ọ na-akwụsị kappa B kinase, enzyme na-arụ ọrụ NF-kB, ihe na-agbanwe cytokines mkpali [1].

 

Akụkọ banyere alfa-lipoic acid

Snell chọpụtara na alfa-lipoic acid na 1937. N'oge ahụ, ndị ọkà mmụta sayensị na -amụ ụdị nje bacteria na -eji ihe ọ potatoụ potatoụ nduku eme ya. Na 1n 1951, Reed kewapụrụ ya. Ejiri ọgwụ izizi malitere na Germany na 1959 maka ịgwọ nsị n'ihi olu mkpuchi ọnwụ.

Ozi gbasara iji alfa-lipoic acid na arụmọrụ ya emebeghị. FDA enwetabeghị ojiji ọ na -eji agwọ ọrịa. Mana n'ime afọ ndị gafeworonụ, ọ nwetala ewu ewu dịka mgbakwunye.

 

Kedu ihe bụ mmetụta nke alfa-lipoic acid?

Dị ka ọtụtụ ọgwụ ndị ọzọ, alfa-lipoic acid nwekwara mmetụta ụfọdụ.

Offọdụ mmetụta ndị na-emetụtakarị alfa-lipoic acid bụ:

  • isi ọwụwa
  • Ọkụ obi nro
  • ọgbụgbọ
  • vomiting
  • Mmetụta ihe
  • Isi ncha
  • Ọbara ọbara dị ala
  • Akpụkpọ ahụ ọkụ
  • Mmanya

A maghị mmetụta alfa-lipoic acid n'ahụ ndị dị ime na ndị na-enye nwa ara. Ya mere, a na -atụ aro ka ị zere iji nke a mgbe ị dị ime ma ọ bụ na -enye nwa ara.

 

Kedu uru nke alfa lipoic acid?

Enwere uru dị iche iche nke alfa-lipoic acid. Ha bụ:

 

Mmetụta na Ọrịa Alzheimer

Alfa-lipoic acid ntụ ntụ nwere ikike igbu oge mmalite ma ọ bụ belata nrịanrịa nke ọrịa neurodegenerative. Emere ọmụmụ ihe na mmadụ itoolu nwere ọrịa Alzheimer. A na-enye 600mg nke alfa-lipoic acid kwa ụbọchị maka ọnwa 12 [2]. Ọ nwere ike ime ka cognition sie ike na ndị ọrịa a. Ngwongwo antioxidant ya nwere ike belata ọnọdụ ahụ wee nwee ike rụọ ọrụ dị ka onye na -ahụ maka neuroprotective.

 

Mmetụta na Ọrịa shuga

Alfa-lipoic acid nwere ike inye aka belata ọkwa shuga dị n'ọbara na ndị ọrịa mamịrị. Ebe ọ bụ na akụrụngwa antioxidant ya nwere ike wepu radicals n'efu n'ahụ, ọ nwere ike inye aka gwọọ mmebi nke mkpụrụ ndụ nke ọrịa shuga kpatara. Ọ nwekwara ike melite iguzogide insulin n'ime ndị ọrịa mamịrị. Ọ nwere ike igbochi ọnwụ mkpụrụ ndụ beta ma nwee ike ịkwalite nnabata glucose ma belata nsogbu nke ọrịa shuga, ọkachasị neuropathy na -arịa ọrịa shuga [3].

 

Mmetụta na Ọrịa strok

Alfa-lipoic acid nwere ikike neuroprotective. Omume antioxidant ya nwekwara ike inye aka n'ịba ụba neuron na ụbụrụ nke nwere ọrịa strok. Nnyocha e mere na oke nwere ọrịa strok ischemic nke enyere alfa-lipoic acid gosipụtara mmụba na ọnọdụ ha [4]. N'ihi ya, ọ nwere ike inye aka melite ọnọdụ ndị ọrịa strok.

 

Mmetụta na ịka nká

Alfa-lipoic acid ntụ ntụ nwekwara ike nwee ike inye aka belata ịka nká nke akpụkpọ ahụ. Alfa-lipoic acid nwere ike inye otu elektrọn ka ihe na-emebi akpụkpọ na ịka nká na-akpata ihe na-arụ ọrụ ma na-egbu onwe ya. N'ụzọ dị otu a, ọ nwere ike kwụsị ịka nká yana nwekwara ike mejupụta ọrụ nke akụkụ antioxidant na -adịghị ike [5]. Nke a nwekwara ike inye aka megide mmebi nke ihe dị iche iche kpatara.

 

Mmetụta dị na nsị Mercury na Autism

Alfa-lipoic acid nwere ike ịgafe ihe mgbochi ụbụrụ ọbara. E nwedịrị ike iji ya mebie mercury dị na mkpụrụ ndụ ụbụrụ ma ọ bụrụ nsị nsị mercury [6]. Ọ nwere ike kpọkọta mercury agbụ n'ime ọbara site na ebe ndị ọrụ chelator ndị ọzọ dị ka dimercaptosuccinic acid (DMSA) ma ọ bụ methylsulfonylmethane (MSM) nwere ike ibufe mercury n'ime akụrụ ya wee wepụta ya na mmamịrị. Ebe ọ bụ na DMSA ma ọ bụ MSM enweghị ike ịgafe mgbochi ụbụrụ ụbụrụ, iji alpha-lipoic acid na DMSA nwere ike inye aka wepu mercury n'enweghị nsogbu. Nke a nwekwara ike nyere aka gwọọ autism dịka ụmụaka autistic nwere ọkwa mercury dị elu na ụbụrụ ha ma e jiri ya tụnyere nke nkịtị. Agbanyeghị, ọmụmụ gbasara nke a pere mpe.

 

Mmetụta na anaemia

Emere ọmụmụ maka ndị ọrịa nwere ọrịa akụrụ na-akwụsị na anaemia ebe enyere alfa-lipoic acid ndị ọrịa [7]. Ọ gosipụtara na ọ nwere ike dị ka erythropoietin n'ịbawanye ọkwa hemoglobin na -enweghị mmetụta ọ bụla na -emerụ ahụ. N'ihi ya, ọ nwere ike inye aka n'ịgwọ ọrịa anaemia nke sitere na ọdịda akụrụngwa na-akwụsị. Ọ nwekwara ike ịba uru na akụ na ụba.

 

Mmetụta dị ka Antioxidant

Ebe ntụ ntụ alfa-lipoic acid bụ antioxidant, ọ nwere ọtụtụ uru ma nwee ike inye aka n'ọtụtụ ọnọdụ dị na ahụ.

 

Mmetụta na Neurotoxicity n'ihi mmanya na -egbu egbu

Mmanya na -aba n'anya nwere ike ibute ọrịa akwara ozi n'ihi nrụgide oxidative. Alfa-lipoic acid nwere ike inye aka gwọọ neurotoxicity n'ihi mmanya. Ọ nwere ike igbochi oxidation protein nke na -eme na oriri ethanol [8].

 

Mmetụta na Mbelata Ibu

Alfa-lipoic acid nwekwara ike bụrụ ezigbo mgbakwunye maka inye aka n'ibelata ibu maka ndị buru oke ibu na ndị buru oke ibu [9]. Ọ nwere mmetụta dị ala ma e jiri ya tụnyere ọgwụ ndị ọzọ na -efunahụ ibu ma nwee ọgwụ antioxidants nke nwere ike inye aka mee ka ahụ dị mmadụ mma.

 

Contraindications

Enweghị ọtụtụ ọmụmụ na contraindications nke alfa-lipoic acid. Agbanyeghị, ụfọdụ ndị ọrịa nwere ọnọdụ ụfọdụ ga -akpachara anya tupu ha ejiri ihe a wee gakwuru dọkịta tupu ha ejiri ya.

Ụfọdụ ọnọdụ ndị a bụ:

  • Ọrịa afọ ime
  • Ịṅụ oké mmanya
  • thyroid ọrịa
  • Ọrịa Thiamine

 

Mmekọrịta ọgwụ na alfa-lipoic acid

Enweghị ọtụtụ ozi gbasara mmekọrịta alfa-lipoic acid na ọgwụ ndị ọzọ. Mana ụfọdụ ọgwụ kacha mma ka a ga -ezere ya na mgbakwunye a.

Ụfọdụ n'ime ọgwụ ndị a bụ:

Ọgwụ hypoglycemic -Alfa-lipoic nwere ikike ibelata shuga ọbara. N'ọnọdụ ụfọdụ, ọ nwere ike ibute ọrịa autoimmune insulin, na -eduga na hypoglycemia. Yabụ na iji ya na ọgwụ hypoglycemic nwere ike ibute hypoglycemia ngwa ngwa nke nwere ike ịdị ize ndụ.

Ọgwụ thyroid -Alfa-lipoic acid nwere ike belata ọkwa homonụ thyroid. Yabụ na achọrọ nlebara anya nke ọma mgbe ejiri ya na levothyroxine.

 

Ebee ka ị nwere ike zụta alfa-lipoic acid na 2021?

Ị nwere ike zụta ntụ ntụ alfa-lipoic acid ozugbo site na ụlọ ọrụ na-emepụta alfa-lipoic acid. A na -enweta ya na ezigbo odo odo na ntụ ntụ odo. A na -etinye ya na ngwugwu nke 1 n'arọ kwa ngwugwu na kilogram 25 n'otu mkpọ. Agbanyeghị, enwere ike gbanwee nke a dabere na mkpa onye zụrụ ya.

Ekwesịrị ịchekwa ya na okpomọkụ nke 0 ruo 4 Celsius maka obere oge yana -20 Celsius C maka ogologo oge. Ọ chọrọ ebe oyi, ọchịchịrị, na nkụ maka ịchekwa ya ka ọ ghara ime ihe na kemịkal ndị ọzọ na gburugburu. Emere ngwaahịa a site na ngwa kachasị mma na -eso usoro kwesịrị ekwesị.

 

Ihe e zoro aka na ya

  1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Alfa-lipoic acid na-enwe mmetụta mgbochi mkpali na mkpụrụ ndụ mesangial nke lipopolysaccharide na-akpali site na mgbochi nke ihe na-akpata nuklia kappa B (NF-κB). mbufụt, 38(2), 510-519.
  2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid dị ka nhọrọ ọgwụgwọ ọhụrụ maka ọrịa Alzheimer-nyocha ọnwa 48. N'ime Nsogbu Neuropsychiatric Otu Mgbakwunye Mmekọrịta(p. 189-193). Mmiri, Vienna.
  3. Laher, I. (2011). Ọrịa shuga na alfa-lipoic acid. Ala dị ala na ụlọ ọrụ ọgwụ, 2, 69.
  4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Ọgwụ alfa-lipoic acid bụ neurorestorative ma na-akwalite mgbake ọrụ mgbe ọrịa strok na oke. Ụbụrụ molekụla, 8(1), 1-16.
  5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Mmetụta nke α-Lipoic Acid na mmepe nke nha nha akpụkpọ ahụ mmadụ site na iji ụdị akpụkpọ anụ na-enweghị ọnya. Akwụkwọ bụ International Journal of Scholarships, 22(4), 2160.
  6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Nghọta na alpha-lipoic na dihydrolipoic acid dị ka ndị na-ekwe nkwa nrụgide nrụgide oxidative yana ndị chelators nwere ike na toxicology mercury. Akwụkwọ akụkọ biochemistry inorganic, 195, 111-119.
  7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Ọrụ nke alfa-lipoic acid na njikwa anaemia na ndị ọrịa nwere ọdịda akụrụngwa na-adịghị ala ala na-aga hemodialysis. Akwụkwọ akụkọ mba ụwa nke nephrology na ọrịa nwughari, 6, 161.
  8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Alfa-lipoic acid na-egbochi oxidation protein na-akpata ethanol na sel hippocampal HT22 òké. Neuroscience Akwụkwọ edemede, 328(2), 93-96.
  9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alfa lipoic acid (ALA) dị ka mgbakwunye maka oke ibu: nsonaazụ sitere na nyocha meta nke ọnwụnwa na -achịkwa nke enweghị usoro. Nyocha Nnyocha, 18(5), 594-601.

 

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