Oleoylethanolamide (OEA): Ọgwụ Mgbu Na-akpata Nke Na-enyere Gị Aka ịchịkwa Agụụ

Gịnị bụ Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) bụ ihe ndozi na-achịkwa ibu arọ, cholesterol na agụụ. A na-arụpụta metabolite na obere obere n'ime eriri afọ. Molekul anụ ahụ bụ maka mmetụta nke njupụta mgbe ị risịrị nri. Oleoylethanolamide na-enye aka ịhazi abụba ahụ site na ijikọta Peroxisome proliferator-arụ ọrụ alpha (PPAR-Alpha). Mkpụrụ ndụ a na-edozi ahụ na-eme ka ahụ abụba na-eme ka ụbụrụ gị mara nke ọma ma na-agwa ụbụrụ gị na ị nara nri zuru oke ma na ị ga-akwụsị iri nri. Oleoylethanolamide na-emekwa ka mmefu calorie metụtara mmega ahụ.

Kedu ka Oleoylethanolamide (OEA) si arụ ọrụ?

Usoro Oleoylethanolamide (OEA)

OleoylethanolamideOAS) ọrụ dịka nchịkwa agụụ. Oleoylethanolamide na-achịkwa nri gị site na izipu akara na ụbụrụ na-agwa ya na i tojuru, na oge eruola ịkwụsị iri nri. N'ihi nke a, ị na-eri obere nri kwa ụbọchị, ahụ gị na-akwụsị ịkwakọbukwu ibu karịa ogologo oge.

Oleoylethanolamide (OEA) (111-58-0) ewepụtara ma chịkọta ya na obere eriri afọ site na oleic acid sitere na nri. Ihe oriri nwere nnukwu abụba nwere ike igbochi imepụta Oleoylethanolamide n'ime obere eriri afọ.

Oleoylethanolamide na-eme ka nri rie nri belata site na-akpali ụbụrụ ụbụrụ histamine, homeostatic oxytocin, na hedonic dopamine way. O doro anya na Oleoylethanolamide nwekwara ike belata akara nrịbama nke CB1R, nke ọ bụrụ na a kpalie ya nwere ike ibute ị foodụ nri. Oleoylethanolamide na-ebelata njem ọdụdụ n’ime adipocytes iji belata oke abụba.

OEA na-arụkwa ọrụ iji kpalie ihe a maara dịka PPAR ma n'otu oge na-ebelata nchekwa abụba ma na-abawanye oke abụba. Mgbe ọ bụla ị riri nri, ọkwa OEA na-ebili, agụụ ị ga-ada. Nke a na - eme n'ihi na mọzụlụ jikọrọ ụbụrụ gị na - agwa ya na ị na - ekele PPAR-full. PPAR-α bụ ihe nnabata nke ligand na-arụ ọrụ nke na-etinye aka na ụzọ homeostasis ike na ngosipụta nke metabolism metabolism.

Oleoylethanolamide (OEA) na-egosiputa agwa niile na-akọwapụta satiety factor nke gụnyere:

• Na igbochi iri nri site na ịbawanye oge n’agbata otu nri na nri nke ọzọ;
• Ihe omumu ya bu ihe eji edozi ya
• Ọ na-eto ọ̀tụ̀tụ̀ mmiri ga-agaghari.

Oleoylethanolamide (OEA) Uru

Oleoylethanolamide uru ọphu ẹhu atsọkwa mu ẹna;

i. Mbelata agụụ na-akpali akpali homonụ nke akpọrọ Ghrelin

Ingụọ peripheral nke OEA ji ụmụ irighiri ihe nke na-ebu ọnụ maka otu ụbọchị emetụtaghị hotelin hormone n'ime nkeji iri abụọ, mana mgbe awa isii gasịrị, mbelata nke a dị ukwuu site na pasent 120 ruo 6. Agbanyeghị, Oleoylethanolamide enweghị mmetụta na ntanetị nke agụụ a na - akpali homonụ na akụrụ nri. Nke a na-egosi na mgbakwunye OEA na-arụ ọrụ kachasị mma n'ibelata ọkwa ghrelin ma ọ bụrụ na ewere ya tupu nri.

ii. Increbawanye ụba nke oke abụba

Ndị βeta-adrenergic ndị na-anabata ọrụ na-arụ ọrụ iji mee ka ahụ nwee ume dị ukwuu ma gbaa ume na βeta3-adrenergic receptor na-ebute mbelata nri oriri na oke abụba na oke. Onye na-anabata ihe na-eme nke a site na-akpali protein na-enweghị ike gụnyere UCP1.

N'ihi ya, ngalaba-nchịkwa nke agonist β3 na ọgwụ oleoylethanolamide dị n'akụkụ dị ka ọ dị irè n'ibelata nri nri yana ịrụ ọrụ nke ọma n'ibelata oke abụba metụtara ịrị elu mmefu nke ike. Nrịgo elu nke UCP1 na PPARα (echere iji gosipụta mmefu ike) mere na anụ aja aja na ọcha na anụ ọcha tinyere nkwalite na mitochondrial biomarkers.

Ya mere OEA gosiputara mmetuta nke metabolic na mitochondrial na mmezu ihe nke thermogenic na akwara ya na akwara agba aja aja na ọcha na-acha ọcha, n'otu usoro onyoylethanolamide dị ka nke ahụ si ejikwa agụụ.

iii. Mbelata ọkwa nke Peptide YY (Hormone agụụ

Injections nke 5mg / kg Oleoylethanolamide na òké mere ka mbelata nke mmiri ọgwụ YY peptide nke na-ewepụta na eriri afọ ma nri afọ ma nri anaghị eri.

Oleoylethanolamide (OEA) Ọ na-enyere aka ịchịkwa agụụ?

Ee. Oleoylethanolamide aro ọnwụ mgbakwunye na-enyere aka ịchịkwa agụụ site na ime ka PPAR na-ebelata ibelata abụba na ịba ụba nke abụba. Mgbe ị na-eri nri, ọkwa Oleoylethanolamide na-ebili ma na-ebelata agụụ ka ị rie nri mgbe ezigara ụbụrụ gị na-agwa ụbụrụ na i nwere afọ ojuju.

Enweela ọtụtụ ọmụmụ sayensị na-egosi mmetụta a. Dịka ọmụmaatụ, na 2004, ndị nchọpụta Denmark nyochara ụmụ oke na anaghị eri nri maka otu ụbọchị. Ha nyere ha OEA wee chọpụta na ego nri ha riri belatara site na 15.5%. N'okwu dị mfe, Oleoylethanolamide (OEA) na-agbanyụ mgbanwe maka agụụ na CNS (Central Nerror System).

Oleoylethanolamide (OEA) Ọgwụ

Usoro ọgwụgwọ oleoylethanolamide na-atụ aro bụ otu capsule 200mg mgbe ewere ya na enweghị nchikota ọ bụla. Mgbe ejikọtara ya na ihe ndị ọzọ na-eme ka ịdị arọ ya belata, a ga-agbadata ọgwụ OEA n'etiti 100mg na 150mg.

A na-atụ aro ka ị oleụ ntakịrịoylethanolamide nkeji 30 tupu nri abalị ma ọ bụ nri ụtụtụ; satisfied ga-enwe afọ ojuju karịa n'oge nri gị, ị ga-ejikwa obere nri.

Nnyocha na-egosi na ị nwekwara ike belata ma ọ bụ nwekwuo usoro ọgwụ kwa ụbọchị dabere na ahụ gị dị ukwuu. Dịka ọmụmaatụ, ọ bụrụ na ị tụọ 150lb, ị nwere ike were 100mg. Onye 200lb nwere ike were 150mg ma mmadụ 250lb nwere ike were 180mg nke mgbakwunye ahụ.

Mmetụta Oleoylethanolamide (OEA)

Oleoylethanolamide mmetụta utịp nwere ike bụrụ nnukwu nchegbu n’etiti ndị nrụpụta mgbakwunye chọrọ ịgụnye ihe dị ike a na usoro ịgbakwunye oke ibu ha.

Mgbe nyochachara nke nyocha sayensị niile dị, US FDA (nchịkwa nri na ọgwụ nchịkwa) enweghị nsogbu gbasara nchekwa nke mkpụrụ ndụ ihe eke a. RiduZone bụ OEA ntụ ntụ nke mbụ emere akara na 2015.

OEA bụ metabolic oleic acid na akụkụ nke nri ụbọchị ọ bụla. Ọ dị mma ịnara mgbakwunye Oleoylethanolamide ebe ọ bụ na ọ nweghị ọghọm nsonaazụ akọtụrụla.

Oleoylethanolamide (OEA) Zụrụ

Nwere ike nweta ịzụta oleoylethanolamide site na ọtụtụ ụlọ ahịa ọgwụ n'ịntanetị na nke anụ ahụ. Ọ ga-adị mkpa ka ị kpachara anya ebe ọ bụghị na ndị na-ebunye gị ihe niile dị mma. Jide n'aka na ị gụrụ nyocha oleoylethanolamide iji mara ihe ahụmịhe nke ndị zụrụ ha na mbụ.

You na-eche ebe ị ga-enweta oleoylethanolamide maka ọrịre? Echegbula; ị nwere ike ịzụta oleoylethanolamide na ntanetị ebe a na weebụsaịtị anyị. Anyị bụ onye a ma ama na onye nwere ahụmahụ OAS soplaya ma anyị nwere ikike ịnapụta Oleoylethanolamide (OEA) na USA na ọtụtụ mba ndị ọzọ gburugburu ụwa. Usoro anyị dị mfe mana nchekwa zuru oke ma dịkwa nchebe. Anyị na-anapụta ngwaahịa anyị na ngwugwu ejiri akara ma mara mma iji hụ nchekwa ma zere mmetọ ọ bụla.

Nkeji edemede site:

Dọkịta Liang

Co-guzobere, onye isi ụlọ ọrụ na-edu ndú; PhD natara na Fudan University na organic onwu. Ihe karịrị afọ itoolu nke ahụmịhe na njikọ njikọ nke kemịkal ọgwụ. Ahụmịhe bara ụba na kemịlị jikọtara ọnụ, kemịkal ọgwụ na njikọta omenaala na njikwa ọrụ.

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